Biological Activity of an Intravenous Preparation of Human Vaccinia Immune Globulin in Mouse Models of Vaccinia Virus Infection
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چکیده
منابع مشابه
Biological activity of an intravenous preparation of human vaccinia immune globulin in mouse models of vaccinia virus infection.
The biological activity of a new intravenous (i.v.) preparation of human vaccinia immune globulin (VIGIV) was evaluated in two mouse models of vaccinia virus (VV) infection. In a mouse tail lesion model, female CD-1 mice were inoculated i.v. with 7 x 10(4) PFU of VV to produce >10 lesions per tail 8 days later. In a mouse lethality model, female severe combined immunodeficient (SCID) mice were ...
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15 صفحه اولSafety and pharmacokinetic evaluation of intravenous vaccinia immune globulin in healthy volunteers.
BACKGROUND Vaccinia immune globulin (VIG) administered via the intramuscular route has historically been used for the treatment of complications of smallpox vaccination. Intravenous formulations of VIG are required to improve tolerability and pharmacokinetic profile. METHODS We conducted 2 separate studies to evaluate the feasibility of administration of an intravenous formulation of antivacc...
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BACKGROUND Numerous literature reports describe clinical efficacy of intramuscular vaccinia immune globulin (VIG) for complications of smallpox vaccination, prophylaxis of individuals with contraindications to vaccination, and prevention of smallpox among close contacts of patients with smallpox. METHODS We reviewed the literature regarding VIG treatment and prophylaxis of smallpox vaccine co...
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Although Vaccinia virus (VACV) was used to eradicate smallpox by dermal vaccination, there is little information available about the immune response induced at the vaccination site. Previously, an intradermal murine model that mimics smallpox vaccination was established. Here, this model was used to investigate which leukocytes are recruited to the infected lesion and what are the kinetics of r...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2005
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.49.7.2634-2641.2005